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(+/-)-Narwedine 结构式

(+/-)-那维定

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货号 :BCP17760CAS号 :1668-86-6纯度:98%
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  • 基本信息与产品描述
CAS号 1668-86-6 货号 BCP17760
中文名 (+/-)-那维定
英文名 (+/-)-Narwedine
中文别名 左旋那维定;消旋那维定单耗;消旋那维定;(+/-)-那维定(消旋那维定);
英文别名 Galanthaminone;
SMILES CN1CCC23C=CC(=O)CC2OC4=C(C=CC(=C34)C1)OC
化学名称
分子式 C17H19NO3 分子量 285.34
纯度 98% 配送 惯例下常温包邮
产品描述 Narwedin is a competitive and reversible cholinesterase(AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. IC50 value: Target: AChE Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release. Absorption of galantamine is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
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