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| CAS号 | 1995889-48-9 | 货号 | BCP42656 |
| 中文名 | Parsaclisib hydrochloride | ||
| 英文名 | Parsaclisib hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Parsaclisib HCl;INCB50465 HCl; INCB-50465; INCB 50465; INCB050465 HCl; INCB-050465; INCB 050465; | ||
| SMILES | CCOC1=C(C(=C(C=C1C(C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)C4CC(=O)NC4.Cl | ||
| 化学名称 | |||
| 分子式 | C20H23Cl2FN6O2 | 分子量 | 469.34 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Parsaclisib, also known as INCB050465, is a novel PI3Kδ inhibitor which synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. INCB050465 inhibits PI3Kδ (IC50 = 1 nM at 1 mM ATP) with approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. INCB050465 demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM. In addition, INCB050465 blocks the proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM) and can slow tumor growth in the Pfeiffer model of DLBCL in vivo. | ||
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