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JNJ-63576253 结构式

JNJ-63576253

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货号 :BCP41266CAS号 :2110428-64-1纯度:98%
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  • 基本信息与产品描述
CAS号 2110428-64-1 货号 BCP41266
中文名 JNJ-63576253
英文名 JNJ-63576253
中文别名
英文别名 TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253;
SMILES C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F
化学名称
分子式 C23H21F3N6O2S 分子量 502.52
纯度 98% 配送 惯例下常温包邮
产品描述 TRC253, also known as JNJ63576253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.
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