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| CAS号 | 221244-14-0 | 货号 | BCP09491 |
| 中文名 | 1 NM-PP1 | ||
| 英文名 | 1 NM-PP1 | ||
| 中文别名 | |||
| 英文别名 | 1-Naphthylmethyl-PP1;NM-PP1;Mutant Kinases Inhibitor II; 1NM-PP1; 1NM PP1; 1NMPP1;1-NM-PP1;PP1 Analog II; | ||
| SMILES | NC1=C2C(N(C(C)(C)C)N=C2CC3=C4C=CC=CC4=CC=C3)=NC=N1 | ||
| 化学名称 | |||
| 分子式 | C20H21N5 | 分子量 | 331.41 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | 1 NM-PP1 is a potent Mutant Kinases Inhibitor.1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems. | ||
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