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| CAS号 | 233277-99-1 | 货号 | BCP48070 |
| 中文名 | K-11777 | ||
| 英文名 | K-11777 | ||
| 中文别名 | |||
| 英文别名 | APC-3316; APC3316; APC 3316; K 11777; K11777; K 777; K-777; K777; CRA-3316; CRA3316; CRA 3316; | ||
| SMILES | CN1CCN(CC1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCC3=CC=CC=C3)C=CS(=O)(=O)C4=CC=CC=C4 | ||
| 化学名称 | |||
| 分子式 | C32H38N4O4S | 分子量 | 574.73 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | K-11777 is a a potent, irreversible cysteine protease inhibitor and a potent and selective CCR4 antagonist. Its therapeutic targets are cruzain, a cysteine protease of the protozoan parasite Trypanosoma cruzi, and cathepsins B and L, which are associated with cancer progression. K777 inhibited both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells (IC50: 57 and 8.9 nmol/l, respectively). K777 induced CCR4 internalization, with a ∼50% reduction of cell surface CCR4. K777 did not inhibit CXCR4-induced chemotaxis or internalization and did not bring about Ca(2+) mobilization by itself. | ||
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