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| CAS号 | 260417-62-7 | 货号 | BCP46387 |
| 中文名 | SG2057 | ||
| 英文名 | SG2057 | ||
| 中文别名 | |||
| 英文别名 | SG-2057; SG 2057; | ||
| SMILES | COC1=C(C=C2C(=C1)C(=O)N3CC(=C)CC3C=N2)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=C)CN6C5=O)OC | ||
| 化学名称 | |||
| 分子式 | C33H36N4O6 | 分子量 | 584.66 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48 h period. Significant antitumor activity was demonstrated in several human tumor xenograft models. | ||
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