靛玉红

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02284CAS号：479-41-4纯度：98%

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CAS号	479-41-4	货号	BCP02284
中文名	靛玉红
英文名	Indirubin
中文别名
英文别名	Couroupitine B;Indigo red 906748-38-7;
SMILES
化学名称
分子式	C16H10N2O2	分子量	262.26
纯度	98%	配送	惯例下常温包邮
产品描述	Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin inhibits CDKs activity with IC50 of 2.2 - 10 μM resulting in cell cycle arrest in the G2/M phase.Indirubin also inhibits GSK-3β with an IC50 of 0.6 μM, attenuating CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states.It also suppresses tumor necrosis factor (TNF)-induced NF-κB activation in a dose- and time-dependent manner. Indirubin also suppresses the NF-κB activation induced by various inflammatory agents and carcinogens. Indirubin blocks the phosphorylation and degradation of IκBα through the inhibition of activation of IκBα kinase and phosphorylation and nuclear translocation of p65.