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Fludrocortisone acetate 结构式

醋酸氟氢可的松

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货号 :BCP38927CAS号 :514-36-3纯度:98%
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  • 基本信息与产品描述
CAS号 514-36-3 货号 BCP38927
中文名 醋酸氟氢可的松
英文名 Fludrocortisone acetate
中文别名
英文别名 Fludrocortisone 21-acetate;
SMILES CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)O
化学名称
分子式 C23H31FO6 分子量 422.49
纯度 98% 配送 惯例下常温包邮
产品描述 Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
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