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Isavuconazonium 结构式

艾沙康唑

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货号 :BCP23773CAS号 :742049-41-8纯度:98%
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  • 基本信息与产品描述
CAS号 742049-41-8 货号 BCP23773
中文名 艾沙康唑
英文名 Isavuconazonium
中文别名
英文别名 BAL8557; BAL 8557; BAL-8557;
SMILES CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O
化学名称
分子式 C35H35F2N8O5S+ 分子量 717.77
纯度 98% 配送 惯例下常温包邮
产品描述 Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA for the treatment of invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and parenteral formulations. Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration. This formulation also avoids the use of a cyclodextrin vehicle for solubilization required for intravenous administration of other antifungals such as voriconazole and posaconazole, eliminating concerns of nephrotoxicity associated with cyclodextrin.
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