RG7112

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07937CAS号：939981-39-2纯度：98%

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CAS号	939981-39-2	货号	BCP07937
中文名	RG7112
英文名	RG7112
中文别名
英文别名	RG-7112;RG 7112; RO-5045337; RO 5045337; RO5045337;
SMILES	C[C@@]1([C@](C)(N(C(C2=CC=C(C=C2OCC)C(C)(C)C)=N1)C(N3CCN(CC3)CCCS(=O)(C)=O)=O)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
化学名称
分子式	C38H48Cl2N4O4S	分子量	727.78
纯度	98%	配送	惯例下常温包邮
产品描述	RO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.