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SIS3 结构式

SIS3

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货号 :BCP45559CAS号 :1009104-85-1纯度:98%
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  • 基本信息与产品描述
CAS号 1009104-85-1 货号 BCP45559
中文名 SIS3
英文名 SIS3
中文别名
英文别名 SIS-3;SIS 3;Smad3 Inhibitor, SIS3;
SMILES CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5
化学名称
分子式 C28H27N3O3 分子量 453.53
纯度 98% 配送 惯例下常温包邮
产品描述 SIS3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
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