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| CAS号 | 17395-31-2 | 货号 | BCP24882 |
| 中文名 | 常山酮氢溴酸盐 | ||
| 英文名 | Halofuginone hydrobromide | ||
| 中文别名 | |||
| 英文别名 | RU-19110 hydrobromide; | ||
| SMILES | C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br | ||
| 化学名称 | |||
| 分子式 | C16H18Br2ClN3O3 | 分子量 | 495.59 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. | ||
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