度鲁特韦钠盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP11890CAS号：1051375-19-9纯度：98%

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CAS号	1051375-19-9	货号	BCP11890
中文名	度鲁特韦钠盐
英文名	Dolutegravir sodium
中文别名	度鲁特韦钠;
英文别名	Dolutegravir sodium salt;S/GSK1349572 sodium;GSK 1349572A;GSK-1349572A;GSK1349572A;
SMILES
化学名称
分子式	C20H18F2N3NaO5	分子量	441.36
纯度	98%	配送	惯例下常温包邮
产品描述	Dolutegravir (DTG, GSK1349572) is metabolized primarily by uridine diphosphate glucuronyltransferase (UGT)1A1, with a minor role of cytochrome P450 (CYP)3A, and with renal elimination of unchanged drug being extremely low (< 1% of the dose). Fifty-three percent of the total oral dose is excreted unchanged in the feces but it is unknown if all or part of this is due to unabsorbed drug or some percentage of biliary excretion of the glucuronide conjugate which can be further degraded to form the parent compound in the gut lumen. The current Food and Drug Administration (FDA) draft guidance for renal impairment studies states that a pharmacokinetic (PK) study in patients with renal impairment should be conducted even for those drugs primarily metabolized or secreted in bile, because renal impairment can inhibit some pathways of hepatic and gut drug metabolism and transport.

度鲁特韦钠盐 新