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Pocapavir 结构式

Pocapavir

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货号 :BCP20876CAS号 :146949-21-5纯度:98%
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  • 基本信息与产品描述
CAS号 146949-21-5 货号 BCP20876
中文名 Pocapavir
英文名 Pocapavir
中文别名
英文别名 SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073;
SMILES
化学名称
分子式 C21H17Cl3O3 分子量 423.71
纯度 98% 配送 惯例下常温包邮
产品描述 Pocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections.
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