NPS-1034

参考资料仅供科学研究，不可用于个人用途。

货号：BCP15998CAS号：1221713-92-3纯度：98%

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CAS号	1221713-92-3	货号	BCP15998
中文名	NPS-1034
英文名	NPS-1034
中文别名
英文别名	NPS1034;NPS 1034;
SMILES	O=C(C1=C(C)N(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NC=C5C6=CC=CC=C6)=NC=C4)C(F)=C3
化学名称
分子式	C31H23F2N5O3	分子量	551.54
纯度	98%	配送	惯例下常温包邮
产品描述	NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752.