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| CAS号 | 133085-33-3 | 货号 | BCP17735 |
| 中文名 | BIBS 39 | ||
| 英文名 | BIBS 39 | ||
| 中文别名 | |||
| 英文别名 | BIBS-39;BIBS39; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C31H34N4O3 | 分子量 | 510.635 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | BIBS-39 is a novel, nonpeptide angiotensin II receptor antagonist, showing antihypertensive activity. In contrast to the angiotensin II receptor subtype 1 (AT1) selective drug DuP 753, BIBS-39 also displays affinity for the angiotensin II receptor subtype 2. BIBS 39 displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor. BIBS 39 appears to be effective antihypertensives in the model of the renal hypertensive rat. | ||
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