LDN-212854 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP14671CAS号：143259726-6纯度：98%

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CAS号	143259726-6	货号	BCP14671
中文名	LDN-212854
英文名	LDN-212854
中文别名
英文别名	LDN 212854;LDN212854;
SMILES	C12=C(C3=C4N=CC(C5=CC=C(N6CCNCC6)C=C5)=CN4N=C3)C=CC=C1N=CC=C2
化学名称
分子式	C25H22N6	分子量	406.48
纯度	98%	配送	惯例下常温包邮
产品描述	LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. The bone morphogenetic protein (BMP) signaling pathway has essential functions in development, homeostasis, and the normal and pathophysiologic remodeling of tissues. Small molecule inhibitors of the BMP receptor kinase family have been useful for probing physiologic functions of BMP signaling in vitro and in vivo and may have roles in the treatment of BMP-mediated diseases.