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| CAS号 | 356559-20-1 | 货号 | BCP02045 |
| 中文名 | SB 525334 | ||
| 英文名 | SB 525334 | ||
| 中文别名 | |||
| 英文别名 | SB-525334;SB525334; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C21H21N5 | 分子量 | 343.42 |
| 纯度 | >97.7% | 配送 | 惯例下常温包邮 |
| 产品描述 | SB 525334 shows no inhibition in the enzymes ALK2, 3, and 6, with IC50 values > 10 μM. SB 525334 blocks phosphorylation induced by TGF-β1 and nuclear translocation of Smad2/3 in renal proximal tubule cells. SB 525334 also inhibits the increased mRNA expression levels of plasminogen activator inhibitor-1 (PAI-1) and procollagen α1induced by TGF-β1 in A498 renal epithelial carcinoma cells at 1 μM). SB 525334 (1 μM) attenuates the heightened sensitivity to TGF-β1 exhibited by pulmonary artery smooth muscle cells (PASMCs) from patients with familial forms of idiopathic pulmonary arterial hypertension (PAH). | ||
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