LY294002 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP00195CAS号：154447-36-6纯度：98%

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CAS号	154447-36-6	货号	BCP00195
中文名	LY294002
英文名	LY294002
中文别名
英文别名	NSC 697286; SF 1101; LY 294002; LY-294002; NSC-697286; SF-1101; NSC697286; SF1101;
SMILES	O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
化学名称
分子式	C19H17NO3	分子量	307.34
纯度	98%	配送	惯例下常温包邮
产品描述	LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 uM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.