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| CAS号 | 475110-96-4 | 货号 | BCP01867 |
| 中文名 | ZSTK474 | ||
| 英文名 | ZSTK474 | ||
| 中文别名 | |||
| 英文别名 | ZSTK-474;ZSTK 474; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C19H21F2N7O2 | 分子量 | 417.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ZSTK474 is a novel orally applicable phosphoinositide 3-kinase-specific inhibitor that strongly inhibits cancer cell proliferation. Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3β by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth. | ||
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