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DASA-58 结构式

DASA-58

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货号 ：BCP16322CAS号 ：1203494-49-8纯度：98%
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  • 基本信息与产品描述
CAS号 1203494-49-8 货号 BCP16322
中文名 DASA-58
英文名 DASA-58
中文别名
英文别名 DASA58;DASA 58; ML-203; ML 203; ML203; NCGC00185916; NCGC-00185916; NCGC 00185916;
SMILES
化学名称
分子式 C19H23N3O6S2 分子量 453.53
纯度 98% 配送 惯例下常温包邮
产品描述 DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells).DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β.It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.
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