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| CAS号 | 94164-88-2 | 货号 | BCP23555 |
| 中文名 | PKM2 inhibitor | ||
| 英文名 | PKM2 inhibitor | ||
| 中文别名 | |||
| 英文别名 | MDK4882; MDK-4882; MD K4882；PKM2-IN-1; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C18H19NO2S2 | 分子量 | 345.48 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PKM2 inhibitor also known as MDK4882 or PKM2-IN-1 , is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017;138:343-352. Currently there is no formal name. We temporally name it as MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells. | ||
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