Etavopivat 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP46430CAS号：2245053-57-8纯度：98%

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CAS号	2245053-57-8	货号	BCP46430
中文名	Etavopivat
英文名	Etavopivat
中文别名
英文别名	FT-4202;FT 4202;FT4202;
SMILES	C1COC2=C(O1)C=C(C=N2)S(=O)(=O)N3CC4=C(C3)CN(C4)C(=O)C(CO)C5=CC=CC=C5
化学名称
分子式	C22H23N3O6S	分子量	457.5
纯度	98%	配送	惯例下常温包邮
产品描述	Etavopivat is an orally available, small-molecule allosteric activator of the selective red blood cell (RBC) isoform of pyruvate kinase (PK-R), with potential to improve symptoms in sickly cell disease (SCD) patients. Upon oral administration, etavopivat allosterically binds to and activates PK-R, thereby enhancing the glycolytic pathway activity in RBCs. This improves adenosine triphosphate (ATP) levels and reduces 2,3-diphosphoglycerate (2,3-DPG) levels in RBCs. This results in increased oxygen affinity, improved RBC deformability, decreased sickle RBC hemolysis, increased hemoglobin (Hb) levels and improved RBC membrane function. Mutations in PK-R cause deficiency in PK-R which prevents adequate RBC glycolysis, leading to a buildup of the upstream glycolytic intermediate 2,3-DPG and deficiency in the PK-R product ATP.