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| CAS号 | 1361030-48-9 | 货号 | BCP14023 |
| 中文名 | LDC1267 | ||
| 英文名 | LDC1267 | ||
| 中文别名 | |||
| 英文别名 | LDC-1267;LDC 1267; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C30H26F2N4O5 | 分子量 | 560.55 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | in vitro: LDC1267 preferentially inhibits Tyro3,Axl andMer at lownanomolarity, as determined by tracer-based binding assays. Treatment of NKG2D activated NK cells with LDC1267 indeed abolished the inhibitory effects of Gas6 stimulation;LDC1267 had no apparent additional effect in Cbl-b-deficient NK cells. in vivo: wild-type mice treated with LDC1267 showed enhanced cytotoxicity towardsRMAcells overexpressing the NKG2D ligand Rae-1 (RMA-Rae1) to the same extent as C373AKI/KI mice, but had no effect on the already enhanced NK cytotoxicity in Cbl-b-mutant mice. Challenged mice with B16F10 melanoma followed by intraperitoneal LDC1267 treatment. LDC1267 markedly reduced metastatic spreading ofmelanomas; NK1.1 depletion abolished the therapeutic benefits of LDC1267. | ||
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