茚地那韦新

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货号：BCP05711CAS号：150378-17-9纯度：98%

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CAS号	150378-17-9	货号	BCP05711
中文名	茚地那韦
英文名	Indinavir
中文别名	吲地那韦;吲地纳韦;
英文别名	Crixivan;MK-639;L-735524;MK639;L735524;MK 639;L 735524;L 735 524;
SMILES
化学名称
分子式	C36H47N5O4	分子量	613.36
纯度	98%	配送	惯例下常温包邮
产品描述	Indinavir(MK-639) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.MK-639 appears to have significant dose-related antiviral activity and is well tolerated. Inhibition constants (K(i)) of the antiviral drug indinavir for the reaction catalyzed by the mutant enzymes were about threefold and 50-fold higher for PR(L24I) and PR(I50V), respectively, relative to PR and PR(G73S). The dimer dissociation constant (K(d)) was estimated to be approximately 20 nM for both PR(L24I) and PR(I50V), and below 5 nM for PR(G73S) and PR. Crystal structures of the mutants PR(L24I), PR(I50V) and PR(G73S) were determined in complexes with indinavir, or the p2/NC substrate analog at resolutions of 1.10-1.50 Angstrom .

茚地那韦 新