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Indinavir sulfate 结构式

硫酸茚地那韦

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货号 :BCP13525CAS号 :157810-81-6纯度:98%
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  • 基本信息与产品描述
CAS号 157810-81-6 货号 BCP13525
中文名 硫酸茚地那韦
英文名 Indinavir sulfate
中文别名
英文别名 Crixivan sulfate;MK-639 sulfate;L-735524 sulfate;MK639 sulfate;L735524 sulfate;MK 639 sulfate;L 735524 sulfate;
SMILES
化学名称
分子式 C36H49N5O8S 分子量 711.87
纯度 98% 配送 惯例下常温包邮
产品描述 Indinavir(MK-639) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.MK-639 appears to have significant dose-related antiviral activity and is well tolerated . Inhibition constants (K(i)) of the antiviral drug indinavir for the reaction catalyzed by the mutant enzymes were about threefold and 50-fold higher for PR(L24I) and PR(I50V), respectively, relative to PR and PR(G73S). The dimer dissociation constant (K(d)) was estimated to be approximately 20 nM for both PR(L24I) and PR(I50V), and below 5 nM for PR(G73S) and PR. Crystal structures of the mutants PR(L24I), PR(I50V) and PR(G73S) were determined in complexes with indinavir, or the p2/NC substrate analog at resolutions of 1.10-1.50 Angstrom.
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