Brecanavir 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44630CAS号：313682-08-5纯度：98%

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CAS号	313682-08-5	货号	BCP44630
中文名	Brecanavir
英文名	Brecanavir
中文别名
英文别名	GW-0385; GW 0385; GW0385; GW-640385; GW 640385; GW640385; GW-640385X; VX-385; VX 385; VX385;
SMILES	CC1=NC(=CS1)COC2=CC=C(C=C2)CC(C(CN(CC(C)C)S(=O)(=O)C3=CC4=C(C=C3)OCO4)O)NC(=O)OC5COC6C5CCO6
化学名称
分子式	C33H41N3O10S2	分子量	703.82
纯度	98%	配送	惯例下常温包邮
产品描述	Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Brecanavir is by a substantial margin the most potent and broadly active antiviral agent among the PIs tested in vitro.