Tinengotinib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP49223CAS号：2230490-29-4纯度：98%

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CAS号	2230490-29-4	货号	BCP49223
中文名	Tinengotinib
英文名	Tinengotinib
中文别名
英文别名	Tinengotinibum;TT-00420;
SMILES	CC1=C2C(=NN1)NC3=CC(=NC=C3C(=N2)C4=CC=CC=C4Cl)N5CCOCC5
化学名称
分子式	C20H19ClN6O	分子量	394.86
纯度	98%	配送	惯例下常温包邮
产品描述	Tinengotinib is an orally available small molecule inhibitor of Aurora kinases (AKs) A and B, Janus kinases (JAKs), fibroblast growth factor receptors (FGFRs) and vascular endothelial growth factor receptors (VEGFRs), with potential antineoplastic and immunomodulatory activities. Upon oral administration, tinengotinib selectively binds to and inhibits AKs A and B, which inhibit cell division in tumor cells that overexpress AKs. Tinengotinib also targets JAKs that are involved in cytokine signaling and inflammation, and FGFRs and VEGFRs, which are overexpressed in the microenvironment (TME) and contribute to neovascularization, tumor growth and metastasis. These kinases are overexpressed by a wide variety of cancer cell types and drive tumor cell proliferation.