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| CAS号 | 1228591-30-7 | 货号 | BCP08426 |
| 中文名 | TAK-632 | ||
| 英文名 | TAK-632 | ||
| 中文别名 | |||
| 英文别名 | TAK 632; TAK 632; | ||
| SMILES | O=C(NC1=CC(OC2=CC=C3N=C(NC(C4CC4)=O)SC3=C2C#N)=CC=C1F)CC5=CC=CC(C(F)(F)F)=C5 | ||
| 化学名称 | |||
| 分子式 | C27H18F4N4O3S | 分子量 | 554.52 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. In addition, TAK-632 was shown preclinically to be a selective kinase inhibitor targeting pan-RAF kinase activity by testing against a panel of kinases. In both A375 (BRAFV600E) and HMVII (NRASQ61K) xenograft models in rats, TAK-632 demonstrated regressive antitumor efficacy by twice daily, 14-day repetitive administration without significant body weight loss | ||
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