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| CAS号 | 308246-52-8 | 货号 | BCP34017 |
| 中文名 | LMP744 | ||
| 英文名 | LMP744 | ||
| 中文别名 | |||
| 英文别名 | LMP-744; LMP 744; MJ-III-65; MJ-III65; NSC-706744;NSC 706744; NSC706744; | ||
| SMILES | COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCNCCO)OC | ||
| 化学名称 | |||
| 分子式 | C24H24N2O7 | 分子量 | 452.46 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LMP744 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP744 produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts. | ||
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