瑞格非尼

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02105CAS号：755037-03-7纯度：98%

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CAS号	755037-03-7	货号	BCP02105
关联产品	1019206-88-2（瑞格非尼(一水合物)） 835621-07-3（盐酸瑞格非尼）
中文名	瑞格非尼
英文名	Regorafenib
中文别名
英文别名	BAY 734506; BAY734506; BAY-734506;BAY 73-4506;BAY73-4506;
SMILES	C12=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC(NC5CCCCC5)=C1NC=N2
化学名称
分子式	C21H15ClF4N4O3	分子量	482.82
纯度	98%	配送	惯例下常温包邮
产品描述	Regorafenib strongly prevents VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with IC50 of 3 nM. In HAoSMCs, regorafenib suppress PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib also inhibits FGFR signaling in MCF-7 breast cancer (BC) cells stimulated with FGF10. Regorafenib very potently inhibited the mutant receptors KITK642E and RETC634W, with IC50 of approximately 20 nM and 10 nM, respectively. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of approximately 3 nM. Regorafenib prevents the proliferation of FGF2-stimulated HUVECs and of PDGF-BB-stimulated HAoSMCs with IC50 of 127 nM and 146 nM, respectively.