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| CAS号 | 924759-42-2 | 货号 | BCP48539 |
| 中文名 | BT44 | ||
| 英文名 | BT44 | ||
| 中文别名 | |||
| 英文别名 | BT-44; BT 44; | ||
| SMILES | O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=CC=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F | ||
| 化学名称 | |||
| 分子式 | C28H27F4N3O4S | 分子量 | 577.59 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. | ||
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