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| CAS号 | 1079274-94-4 | 货号 | BCP44112 |
| 中文名 | AZD-7451 | ||
| 英文名 | AZD-7451 | ||
| 中文别名 | |||
| 英文别名 | AZD7451; AZD 7451; AZ12607092; AZ 12607092; AZ-12607092; | ||
| SMILES | CC(C)OC1=NNC(=C1)N2C=NC3=C2N=C(C=C3)NC(C)C4=NC=C(C=N4)F | ||
| 化学名称 | |||
| 分子式 | C18H19FN8O | 分子量 | 382.39 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival. | ||
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