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GS441524 结构式

GS441524

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货号 :BCP35590CAS号 :1191237-69-0纯度:98%
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  • 瀚香生物(Biochempartner)的GS441524被文献引用
  • 基本信息与产品描述
CAS号 1191237-69-0 货号 BCP35590
中文名 GS441524
英文名 GS441524
中文别名 瑞德西韦中间体;
英文别名 GS-441524; GS 441524;Remdesivir-metabolite;GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite;
SMILES C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N
化学名称
分子式 C12H13N5O4 分子量 291.26
纯度 98% 配送 惯例下常温包邮
产品描述 GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir.
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