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| CAS号 | 1194961-19-7 | 货号 | BCP13151 |
| 中文名 | PRT-060318 | ||
| 英文名 | PRT-060318 | ||
| 中文别名 | |||
| 英文别名 | PRT 060318;PRT060318; PRT318; PRT-318; PRT 318; P14-276; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C18H24N6O | 分子量 | 340.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PRT-060318, also known as PRT318 or P142–76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. | ||
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