R406

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01933CAS号：841290-80-0纯度：98%

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CAS号	841290-80-0	货号	BCP01933
关联产品	841290-81-1（R406苯磺酸盐）
中文名	R406
英文名	R406
中文别名
英文别名	R-406;R 406;R406 free base;Tamatinib;
SMILES
化学名称
分子式	C22H23FN6O5	分子量	470.45
纯度	98%	配送	惯例下常温包邮
产品描述	R406 is an ATP-competitive inhibitor of Syk with a Ki value of 30 nM. R406 selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM, more potently than Syk-independent pathways in different cells.R406 inhibits cellular proliferation of a large panel of diffuse large B-cell lymphoma (DLBCL) cell lines at EC50 values ranging from 0.8 μM to 8.1 μM. R406 treatment (1 μM or 4 μM) induces the activation of caspases 9 and 3, but not caspase 8, leading to significant apoptosis of the majority of DLBCL cell lines. Pretreatment of R406 completely blocks the phosphorylation of SYK525/526 and the SYK-dependent phosphorylation of BLNK in R406-sensitive DLBCLs following B-cell receptor (BCR) crosslinking. R406 potently decreases MMP-9 mRNA levels by 2.8- and 4.3-fold lower than controls after 24 and 48 hours treatment, respectively, and reduces the invasive capacity of the RL cells.