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R 112 结构式

R 112

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货号 :BCP20695CAS号 :575474-82-7纯度:98%
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  • 基本信息与产品描述
CAS号 575474-82-7 货号 BCP20695
中文名 R 112
英文名 R 112
中文别名
英文别名 R 112 (pharMaceutical);R112; R-112;
SMILES
化学名称
分子式 C16H13FN4O2 分子量 312.3
纯度 98% 配送 惯例下常温包邮
产品描述 R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L).
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