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| CAS号 | 475108-18-0 | 货号 | BCP01980 |
| 关联产品 | 682745-41-1（替沃扎尼盐酸盐一水合物） | ||
| 中文名 | 替沃扎尼 | ||
| 英文名 | Tivozanib | ||
| 中文别名 | |||
| 英文别名 | AV-951;AV951;AV 951; KRN951; KRN 951; KRN-951; | ||
| SMILES | O=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2Cl | ||
| 化学名称 | |||
| 分子式 | C22H19ClN4O5 | 分子量 | 454.86 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. | ||
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