喜树碱新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02857CAS号：7689-03-4纯度：98%

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CAS号	7689-03-4	货号	BCP02857
中文名	喜树碱
英文名	Camptothecin
中文别名
英文别名	Camptothecine (S,+);(S)-(+)-Camptothecin; d-Camptothecin; 20(S)-Camptothecine; (+)-Camptothecin; Camptothecine; CPT;
SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
化学名称
分子式	C20H16N2O4	分子量	348.35
纯度	98%	配送	惯例下常温包邮
产品描述	Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.

喜树碱 新