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| CAS号 | 857876-30-3 | 货号 | BCP01822 |
| 中文名 | 二磷酸莫替沙尼 | ||
| 英文名 | Motesanib Diphosphate | ||
| 中文别名 | |||
| 英文别名 | AMG-706;AMG 706;AMG706; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C22H23N5O.2H3PO4 | 分子量 | 569.44 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Motesanib Diphosphate has broad activity against the human VEGFR family, and displays >1000 selectivity against EGFR, Src, and p38 kinase. Motesanib Diphosphate significantly inhibits VEGF-induced cellular proliferation of HUVECs with an IC50 of 10 nM, while displaying little effect at bFGF-induced proliferation with an IC50 of >3,000 nM. Motesanib Diphosphate also potently inhibits PDGF-induced proliferation and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not effective against the EGF-induced EGFR phosphorylation and cell viability of A431 cells.Althouth displaying little antiproliferative activity on cell growth of HUVECs alone, Motesanib Diphosphate treatment significantly sensitizes the cells to fractionated radiation. | ||
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