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LOXO-195 结构式

LOXO-195

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货号 :BCP20662CAS号 :2097002-61-2纯度:98%
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  • 基本信息与产品描述
CAS号 2097002-61-2 货号 BCP20662
中文名 LOXO-195
英文名 LOXO-195
中文别名
英文别名 LOXO 195; LOXO195;Selitrectinib;
SMILES CC1CCC2=NC=C(C=C2C3CCCN3C4=NC5=C(C=NN5C=C4)C(=O)N1)F
化学名称
分子式 C20H21FN6O 分子量 380.43
纯度 98% 配送 惯例下常温包邮
产品描述 LOXO-195 is a potent and selective TRK inhibitor capable of addressing potential mechanisms of acquired resistance that may emerge in patients receiving larotrectinib (LOXO-101) or multikinase inhibitors with anti-TRK activity. LOXO-195 demonstrated potent inhibition of TRK fusions, including critical acquired resistance mutations, in enzyme and cellular assays, with minimal activity against other kinases. In diverse TRK fusion mouse models, LOXO-195 inhibited phospho-ERK and caused dramatic tumor growth inhibition, superior to first generation TRK inhibitors, without significant toxicity.
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