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ARQ 197 Chemical Structure

ARQ 197

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP28549CAS No. ：1000873-98-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1000873-98-2 Cat. No. BCP28549
Name ARQ 197
Synonyms Tivantinib;ARQ-197;ARQ197;
SMILES C1CC2=CC=CC3=C2N(C1)C=C3[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65
Chemical Name
Formula C23H19N3O2 M. Wt 369.42
Purity 98% Storage Store at 4-8°C
Description ARQ-197 is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.
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