Israpafant New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP35479CAS No. ：117279-73-9Purity：98%

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CAS No.	117279-73-9	Cat. No.	BCP35479
Name	Israpafant
Synonyms	Y-24180; Y 24180; Y24180;
SMILES	CC1C2=NN=C(N2C3=C(C=C(S3)CCC4=CC=C(C=C4)CC(C)C)C(=N1)C5=CC=CC=C5Cl)C
Chemical Name
Formula	C28H29ClN4S	M. Wt	489.08
Purity	98%	Storage	Store at 4-8°C
Description	Israpafant (Y-24180) is a drug which acts as a selective antagonist for the platelet-activating factor receptor, and was originally developed for the treatment of asthma. Its chemical structure is a thienotriazolodiazepines, closely related to the sedative benzodiazepine derivative etizolam. However, israpafant binds far more tightly to the platelet-activating factor receptor, with an IC50 of 0.84nM for inhibiting PAF-induced human platelet aggregation, while it binds only weakly to benzodiazepine receptors, with a Ki of 3680nM. Israpafant has been found to inhibit the activation of eosinophil cells and consequently delays the development of immune responses. It has also been shown to have anti-nephrotoxic properties and to mobilize calcium transport.