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BTdCPU Chemical Structure

BTdCPU

Data Sheet For research use only. Not for human use.
Cat. No. :BCP31242CAS No. :1257423-87-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1257423-87-2 Cat. No. BCP31242
Name BTdCPU
Synonyms eIF2–GTP–tRNAiMetTernaryCompInhib,BTdCPU;
SMILES O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C3N=NSC3=C2
Chemical Name
Formula C13H8Cl2N4OS M. Wt 339.19
Purity 98% Storage Store at 4-8°C
Description BTdCPU is an activator of HRI. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Combination therapy with rapamycin, an mTOR inhibitor, and BTdCPU, an activator of HRI, demonstrated additive effects on apoptosis in dex-resistant cells. Thus, specific activation of the eIF2α kinase HRI is a novel therapeutic target in MM that can augment current treatment strategies.
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