GSK-F1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1402345-92-9 | Cat. No. | BCP29575 |
| Name | GSK-F1 | ||
| Synonyms | 1384097-27-1；rac-GSK-F1; | ||
| SMILES | COC1=C(C=C(C=N1)C2=CC3=C(C=C2)N=C(N(C3=O)C4=CC=CC=C4C(F)(F)F)N)S(=O)(=O)NC5=C(C=C(C=C5)F)F | ||
| Chemical Name | |||
| Formula | C27H18F5N5O4S | M. Wt | 603.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK-F1 is a potent inhibitor of PI4KA. It has markedly better pharmacokinetic properties in vivo with respects to GSK-A1 . GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type IIIα (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results. | ||
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