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Pocapavir Chemical Structure

Pocapavir

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20876CAS No. :146949-21-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 146949-21-5 Cat. No. BCP20876
Name Pocapavir
Synonyms SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073;
SMILES
Chemical Name
Formula C21H17Cl3O3 M. Wt 423.71
Purity 98% Storage Store at 4-8°C
Description Pocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections.
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