Repotrectinib New Hot
Data Sheet
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| CAS No. | 1802220-02-5 | Cat. No. | BCP19778 |
| Name | Repotrectinib | ||
| Synonyms | TPX-0005;TPX 0005; TPX0005; | ||
| SMILES | CC1CNC(=O)C2=C3N=C(C=CN3N=C2)NC(C4=C(O1)C=CC(=C4)F)C | ||
| Chemical Name | |||
| Formula | C18H18FN5O2 | M. Wt | 355.37 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.TPX-0005 is a Src/FAK/Janus kinase 2 (JAK2) inhibitor. TPX-0005 plus EGFR TKI suppressed expression and activation of RTKs and downstream signaling intermediates. Co-expression of CDCP1 and AXL is often observed in EGFR-mutation-positive tumors, limiting the efficacy of EGFR TKIs. Co-treatment with EGFR TKI and TPX-0005 warrants testing. | ||
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