TAK-981 New
Data Sheet
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| CAS No. | 1858276-04-6 | Cat. No. | BCP30806 |
| Name | TAK-981 | ||
| Synonyms | TAK 981; TAK981; | ||
| SMILES | O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=CC([C@@H]4NCCC5=C4C=C(Cl)C=C5)=C(C)S3)=O)C1)(N)=O | ||
| Chemical Name | |||
| Formula | C25H28ClN5O5S2 | M. Wt | 578.10 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TAK-981 is a potent and selective sumoylation inhibitor. TAK-981 targets and covalently binds to the small ubiquitin-like modifier (SUMO; small ubiquitin-related modifier) protein, forming an adduct with SUMO protein (TAK-981-SUMO adduct). This prevents the transfer of SUMO from the SUMO-activating enzyme (SAE) to SUMO-conjugating enzyme UBC9. This prevents SUMO conjugation to lysine residues on target proteins and abrogates many sumoylated protein-mediated cellular processes that play key roles in tumor cells, including proliferation, DNA repair, metastasis and survival. | ||
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