E3 ligase Ligand 1A New
Data Sheet
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| CAS No. | 1948273-02-6 | Cat. No. | BCP32648 |
| Name | E3 ligase Ligand 1A | ||
| Synonyms | VHL ligand 2;(S,R,S)-AHPC-Me; | ||
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O | ||
| Chemical Name | |||
| Formula | C23H32N4O3S | M. Wt | 444.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | E3 ligase Ligand 1A is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. | ||
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