Enpatoran hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2101945-93-9 | Cat. No. | BCP48403 |
| Name | Enpatoran hydrochloride | ||
| Synonyms | M5049 hydrochloride; | ||
| SMILES | C1C(CN(CC1N)C2=C3C=CC=NC3=C(C=C2)C#N)C(F)(F)F.Cl | ||
| Chemical Name | |||
| Formula | C16H16ClF3N4 | M. Wt | 356.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Enpatoran Hydrochloride is a potent and orally active inhibitor of TLR7/8, with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. Enpatoran Hydrochloride had no activity on TLR3, TLR4 and TLR9. Enpatoran hydrochloride blocks the synthesis of ligands and natural endogenous RNA ligands. Enpatoran Hydrochloride showed good pharmacokinetic properties in vivo. Enpatoran Hydrochloride can be used in the study of congenital and adaptive autoimmune blockade. | ||
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